The cellular and molecular biology research center has been set up to support the research faculty members of Babol University of Medical Sciences and other researchers in the field of cellular and molecular sciences on September 10, 2008. Investigating the molecular mechanism involved in the pathogenesis of non-infectious diseases (with an emphasis on common diseases in the region) including cancer, diabetes, cardiovascular diseases, ... is only part of the strategic goals of the center. This center succeeded in reaching the definitive approval on April 13, 2014. Active research teams in collaboration with clinical departments examine new drugs and identify biological markers in various diseases as well as their cellular and molecular mechanisms, and the results are published in various scientific journals or recorded as patent. It should be noted that the center has so far had had 6 PhD by research students.
Regenerative medicine is one of the major areas of activity in the center and based on a decade of laboratory research, with the completion of a clean room at Ayatollah Rouhani Hospital of Babol in 2016, a new phase of research has been started. The center sincerely welcomes researchers and scientists from research projects and announces its readiness for scientific collaboration at various levels.
- Head of Cellular and Molecular Biology Research Center
Dr. Ebrahim Zabihi Neishabouri (PhD)
- PhD of Toxicology- Associate Professor of Pharmacology and Toxicology Department
- Email: e_zabihi@yahoo.com
- Deputy of research
Dr. Hadi Parsian (PhD)
- PhD of Clinical Biochemistry- Associate Professor of Biochemistry
- Email: hadiparsian@yahoo.com
- Center research activities
|
The number of articles indexed in Scopus |
The number of articles indexed in Pubmed |
The number of articles indexed in ISI |
Number of approved projects |
Activities Year |
|
14 |
24 |
11 |
18 |
2013 |
|
14 |
13 |
16 |
26 |
2014 |
|
3 |
10 |
19 |
36 |
2015 |
|
10 |
18 |
37 |
46 |
2016 |
- Research priorities
1. Stem cells (cell therapy, stem cell differentiation, and neuroscience)
2. Common genetic diseases in the region (Thalassemia molecular detection)
3. Investigating the role of genetic factors in the incidence of common cancers in the region (leukemia, gastrointestinal cancer, breast cancer).
4. Pharmacogenetics: Effect of psychotropic drugs on genotypes of individuals
5. Cellular and molecular pharmacology: cytotoxicity assay, in vitro pharmacological evaluation of drugs, regenerative medicine and tissue engineering
6. Effect of medicinal plants: Effect on the treatment of diabetes, immune system (intrinsic and acquired), chemical analysis of related medicinal plants
7. Autoimmunity disorders (Atherosclerosis and Lupus nephritis)
8. Genomix and proteomics with an emphasis on diabetes disorder
9. Cytokines and their role in non-infectious diseases
- Laborator
The laboratory with an area of 175 square meters was set up in 2006, located at the Campus University consisting of two cellular and molecular parts:
- The cell culture laboratory is equipped with two cell culture rooms for isolation, culture and cellular analysis, along with the following accessories and equipment:
- Refrigerator -80
- Laminar hood
- Chemical hood
- Upright and inverted microscopes
- Digital balance
- Vertex
- Dionizer
- CO2 incubator
- Autoclave
- Centrifuge
- pH meter
- Invert microscope
- Water bath
- The objectives of the molecular analysis laboratory are to detect and investigate nucleic acids and proteins.
- Types of studies including quantitative and qualitative gene expression, gene copy number estimation, genotyping determination and genetic disorders diagnosis
- Separation and qualitative evaluation of nucleic acids and proteins, imaging and documentation of nucleic acids and proteins to observe and measure them
- Specific amplification of nucleic acid and low levels of DNA and RNA by PCR method (Polymerase Chain Reaction).
This lab is equipped with the following devices:
- HPLC (High Performance Liquid Chromatography)
- Horizontal and vertical electrophoresis
- 2D electrophoresis
- Gel documentation (Gel doc)
Nanodrop
- Thermocycler:
- Real Time PCR device
- Elisa Reader
- Cell Therapy Unit
Cell therapy unit of cellular and molecular biology research center with an area of over 100 square meters is located on the ground floor of the Ayatollah Rouhani Hospital and is ready for exploitation. This unit requires full hygienic conditions in accordance with international standards to conduct a clinical research using human mesenchymal cells or tissue engineering. The clean room of this unit will conform to the standards of ISO and Ministry of Health and Medical Education. Knowledge-based companies that are active in the field of cell therapy or the production of sterile products to use in the patient's body are collaborating with this unit.
The equipment and devices of this unit are as follows:
- Clean room 2 × 4 square meters
- Air conditioner
- Laminar hood class 2
- CO2 incubator
- Incubator 37 ° C
- Refrigerator
- Autoclave
- Scientific Journal
The International Journal of Molecular and Cellular Medicine (IJMCM) was launched in 2012 and indexed in (Thomson Reuters_Web of Science), ESC, PubMed and Scopus databases. The director is Dr. Ebrahim Zabihi and the Editor-in-Chief is Dr. Haleh Akhavan Niaki.
Objectives: This journal includes all the cellular and molecular biology fields such as genetic basis of the disease, discovery of biology in diagnosis and treatment, genomix and proteomics, bioinformatics, computer programs in human biology, stem cells and tissue engineering, medical biotechnology, nanomaterials, cellular growth-related processes, death and survival, clinical biochemistry, molecular and cellular immunization, molecular and cellular aspects of infectious diseases and cancer research.
- Books
Diagnosis of diseases books based on the findings of the biochemistry (2008) and five hundred points from genome to protein (2015) are other publications of this center, which have been published by the faculty members of the center.
- Recruitment Grant
This center has used national resources for performing its projects with the attraction of research grants from 100 million Rials to 2 billion Rials since its foundation.
- Patent
Meanwhile, the researchers of this center had 2 national patents at the Ministry of Health Patent Committee.
- Holding annual workshops
- Theoretical and practical workshop on Immunohistochemistry and daily pathology response
- Theoretical and practical workshop "Real Time PCR"
- Theoretical and practical workshop "Flow Cytometry"
- Theoretical and practical workshop "Introduction to the principles of cell culture in mammals"
- Theoretical and practical workshop "Principles of PCR and its application in medicine"
- Theoretical and practical workshop "Separation of stem cells from different tissue sources"
- Theoretical and practical preparatory workshop "DNA molecular examination methods"
- Theoretical and practical workshop "Vertical electrophoresis of proteins"
- Theoretical and practical workshop "Elisa"